A method and apparatus for controlling a Radio Frequency Integrated Chip (RFIC) in a wireless communication system are provided. The method includes detecting an event for changing a signal receiving cell of the RFIC, determining whether a Serial Peripheral Interface (SPI) control command for a target cell is pre-stored based on information of the target cell, and configuring the RFIC based on the pre-stored SPI control command if the SPI control command for the target cell is pre-stored.