- 专利标题： Tocopherol and tocopheryl quinone derivatives as correctors of lysosomal storage disorders
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申请号： US15608753申请日： 2017-05-30
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公开(公告)号： US10370348B2公开(公告)日： 2019-08-06
- 发明人: Juan Jose Marugan , Wei Zheng , Jingbo Xiao , John McKew
- 申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as Represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as Represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 主分类号： A01N43/16
- IPC分类号： A01N43/16 ; A61K31/355 ; C07D311/58 ; A61K31/335 ; A61K31/35 ; A61K31/352 ; A61K31/353 ; C07D311/72 ; A61K31/122 ; A61K31/724 ; C07C50/02 ; C07C50/06 ; C07C50/24
摘要：
The subject invention relates to improved tocopheryl quinine derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorder, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.
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