公开(公告)号：US20180110798A1

公开(公告)日：2018-04-26

申请号：US15620753

申请日：2017-06-12

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： John McKew ,  Wei Zheng ,  Miao Xu ,  Manju Swaroop ,  Juan J. Marugan

IPC分类号： A61K31/724 ,  G01N33/92 ,  C08B37/16 ,  A61K45/06 ,  A61K31/355

CPC分类号： A61K31/724 ,  A61K31/355 ,  A61K45/06 ,  C08B37/0012 ,  G01N33/92 ,  A61K2300/00

摘要： The invention provides for methods of treating lysosomal storage disorders and/or reduction of non-cholesterol lipids, using cyclodextrin compounds, including in combination with other therapeutics, including vitamin E.

公开(公告)号：US09663485B2

公开(公告)日：2017-05-30

申请号：US14442637

申请日：2013-11-14

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Juan Jose Marugan ,  Wei Zheng ,  Jingbo Xiao ,  John McKew

IPC分类号： A01N43/16 ,  A61K31/355 ,  C07D311/58 ,  A61K31/335 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  C07D311/72 ,  A61K31/122 ,  A61K31/724 ,  C07C50/02 ,  C07C50/06 ,  C07C50/24

CPC分类号： C07D311/58 ,  A61K31/122 ,  A61K31/335 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/724 ,  C07C50/02 ,  C07C50/06 ,  C07C50/24 ,  C07D311/72

摘要： The subject invention relates to improved tocopheryl quinone derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorders, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.

公开(公告)号：US10370348B2

公开(公告)日：2019-08-06

申请号：US15608753

申请日：2017-05-30

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Juan Jose Marugan ,  Wei Zheng ,  Jingbo Xiao ,  John McKew

IPC分类号： A01N43/16 ,  A61K31/355 ,  C07D311/58 ,  A61K31/335 ,  A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  C07D311/72 ,  A61K31/122 ,  A61K31/724 ,  C07C50/02 ,  C07C50/06 ,  C07C50/24

摘要： The subject invention relates to improved tocopheryl quinine derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorder, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.

公开(公告)号：US11020422B2

公开(公告)日：2021-06-01

申请号：US15620753

申请日：2017-06-12

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： John McKew ,  Wei Zheng ,  Miao Xu ,  Manju Swaroop ,  Juan J. Marugan

IPC分类号： A61K31/724 ,  A61K31/335 ,  A61K45/06 ,  C08B37/16 ,  G01N33/92 ,  A61K31/355

摘要： The invention provides for methods of treating lysosomal storage disorders and/or reduction of non-cholesterol lipids, using cyclodextrin compounds, including in combination with other therapeutics, including vitamin E.

公开(公告)号：US20170260192A1

公开(公告)日：2017-09-14

申请号：US15606740

申请日：2017-05-26

申请人： The United States of America, as represented by the Secretary, Dept of Health and Human Services ,  University of Kansas ,  Northwestern University

发明人： Kevin Frankowski ,  Samarjit Patnaik ,  Sui Huang ,  Juan Jose Marugan ,  John Norton ,  Frank J. Schoenen ,  Noel Terrence Southall ,  Steven Titus ,  Wei Zheng

IPC分类号： C07D487/04 ,  C07F7/18 ,  A61K45/06 ,  A61K31/519 ,  A61K31/695

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/695 ,  A61K45/06 ,  C07F7/1804

摘要： The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.