An actuator for an infusion drive mechanism comprises a piston defining a first axis and being movable within a passageway of the infusion drive mechanism to convey at least one infusion medium. The passageway defines a longitudinal axis. An armature is connected to the piston and defines at least one cavity configured for disposal of a biasing member engageable with a surface of the infusion drive mechanism to orient the first axis transverse relative to the longitudinal axis. Systems and methods of use are disclosed.