A syringe adapter includes a housing having a first end and a second end with the first end configured to be secured to a first container, a cannula having a first end and a second end with the second end of the cannula positioned within the housing, and a collet having a first end and a second end. At least a portion of the collet is received within the housing. The collet includes a body defining a passageway, a membrane received by the passageway, and a locking member connected to the body of the collet. The membrane has a body with a first end and a second end. The body of the membrane defines a passageway. The collet is movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted.