Invention Grant
- Patent Title: Methods of treating diseases associated with fibrosis using modified FGF-21 polypeptides and uses thereof
-
Application No.: US15979881Application Date: 2018-05-15
-
Publication No.: US10377806B2Publication Date: 2019-08-13
- Inventor: Paul E. Morin , Daniel Cohen , Ranjan Mukherjee , Timothy P. Reilly , Rose C. Christian , Dasa Lipovsek , Ray Camphausen , John Krupinski
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: LeClairRyan PLLC
- Agent Robin L. Teskin
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/50 ; A61K45/06 ; A61K47/60 ; A61K47/64 ; A61K38/00
Abstract:
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.
Public/Granted literature
- US20180243375A1 Modified FGF-21 Polypeptides and Uses Thereof Public/Granted day:2018-08-30
Information query
IPC分类:
