Techniques are disclosed to identify a frequently-executed region of code during runtime execution of the code, generate initial profiling code for the frequently-executed region of code, cause the initial profiling code to be executed for a minimum number of processing cycles of the computer, and identify replacement candidate store instruction(s) that store a value that is not read by the frequently-executed region of code during execution of the initial profiling code. Replacement candidate load instruction(s) may also be identified that load a value that is not stored or loaded by the frequently-executed region of code during execution of the initial profiling code. Optimized code for the frequently-executed region of code may be generated by replacing each of the replacement candidate store or load instructions(s) with a non-temporal store or load instruction. The optimized code may be executed instead of the frequently-executed region of code during subsequent runtime execution.