Invention Grant
- Patent Title: Phthalazinones and isoquinolinones as rock inhibitors
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Application No.: US15890436Application Date: 2018-02-07
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Publication No.: US10385026B2Publication Date: 2019-08-20
- Inventor: Peter W. Glunz , Yan Zou , Mimi L. Quan , Vladimir Ladziata
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- Main IPC: C07D237/32
- IPC: C07D237/32 ; C07D401/10 ; C07D401/12 ; C07D403/10 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D417/14 ; C07D513/04 ; C07D405/10 ; C07D217/24 ; C07D413/10 ; C07D417/10 ; C07D471/04 ; C07D487/04 ; C07D491/048
Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Public/Granted literature
- US20180162823A1 PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS Public/Granted day:2018-06-14
Information query
