公开(公告)号：US20230136988A1

公开(公告)日：2023-05-04

申请号：US18046270

申请日：2022-10-13

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC分类号： C07D307/94 ,  C07D405/04 ,  C07D413/04 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/343 ,  C07D405/10 ,  C07D407/12 ,  C07D413/10 ,  C07D413/14

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US11638704B2

公开(公告)日：2023-05-02

申请号：US17354010

申请日：2021-06-22

申请人： Tempest Therapeutics, Inc.

发明人： Yalda Bravo ,  Jason David Burch ,  Austin Chih-Yu Chen ,  Joe Fred Nagamizo

IPC分类号： A61K31/437 ,  A61K31/404 ,  A61K31/41 ,  A61K31/416 ,  A61K31/4184 ,  A61K39/395 ,  C07D209/08 ,  C07D231/56 ,  C07D235/06 ,  C07D403/12 ,  C07D413/10 ,  C07D471/04 ,  A61P35/00 ,  C07D209/18 ,  C07D235/08 ,  C07K16/28

摘要： The present disclosure is directed to novel compounds of Formula I and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g. controlling, alleviating, or slowing the progression of) of cancer, including glioblastoma, bone cancer, head and neck cancer, melanoma, basal cell carcinoma, squamous cell carcinoma, adenocarcinoma, oral cancer, esophageal cancer, gastric cancer, intestinal cancer, colon cancer, bladder cancer, hepatocellular carcinoma, renal cell carcinoma, pancreatic cancer, ovarian cancer, cervical cancer, lung cancer, breast cancer, and prostate cancer. The compounds of the disclosure are selective antagonists of the EP4 receptor and useful treatment of various diseases that may be ameliorated with blockade of PGE2-mediated signaling.

公开(公告)号：US20230091467A1

公开(公告)日：2023-03-23

申请号：US17437192

申请日：2021-01-12

申请人： Qingdao Kingagroot Chemical Compound Co., Ltd.

发明人： Lei LIAN ,  Xuegang PENG ,  Rongbao HUA ,  De ZHAO ,  Qi CUI

IPC分类号： A01N43/80 ,  C07D413/10 ,  C07D413/14 ,  C07D498/04 ,  A01N43/90 ,  C07D471/04 ,  C07D417/12 ,  C07D513/04

摘要： The invention relates to the field of pesticide technology, and in particular a type of fused-ring substituted aromatic compound, preparation method, herbicidal composition and use thereof. The fused-ring substituted aromatic compound, represented by general formula I: wherein, Q represents etc.; Y represents halogen, haloalkyl, cyano, nitro or amino; Z represents H, halogen or hydroxy; M represents CH or N; Het represents a cyclic structure that shares two carbon atoms at 4- and 5-positions with isoxazoline ring to form a fused ring; X1, X2 each independently represent H, halogen or nitro etc. The compound has excellent herbicidal activity against gramineous weeds, broadleaf weeds, etc. even at low application rates, and has high selectivity for crops.

公开(公告)号：US20230086064A1

公开(公告)日：2023-03-23

申请号：US17658587

申请日：2022-04-08

申请人： Nimbus Clio, Inc.

发明人： Silvana Marcel LEIT DE MORADEI ,  Angela V. WEST ,  Thomas BAKER ,  Jokin Carrillo ARREGUI ,  Diana CASTAGNA ,  Jeremy Robert GREENWOOD ,  Salma RAFI ,  Fiona MCROBB ,  Yan ZHANG

IPC分类号： C07D403/10 ,  C07D401/14 ,  C07D471/04 ,  C07D413/14 ,  C07D403/12 ,  C07D413/10 ,  C07D209/44 ,  C07D405/14 ,  C07F5/02 ,  C07D249/08 ,  C07D498/08 ,  C07D491/107 ,  C07D491/048 ,  C07D498/10 ,  A61P35/02

摘要： The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of Cbl-b, and the treatment of Cbl-b-mediated disorders.

公开(公告)号：US20230050777A1

公开(公告)日：2023-02-16

申请号：US17961270

申请日：2022-10-06

申请人： SUZHOU CONNECT BIOPHARMACEUTICALS, LTD.

发明人： Wei ZHENG ,  Wubin PAN ,  Jiawang GUO

IPC分类号： C07D413/10

摘要： Disclosed in the present application are a salt form and a crystal form of an S1P1 receptor mediated disease or symptom drug 1-{2-fluoro-4-[5-(4-isobutylphenyl)-1,2,4-oxadiazole-3-yl]benzyl}-3-azetidinecarboxylic acid (formula A). Also disclosed in the present invention are a preparation method for the salt form or the crystal form, a pharmaceutical composition of the salt form or the crystal form, and use of the salt form or the crystal form in the preparation of a drug for treating and/or preventing an S1P1 receptor mediated disease or symptom.

公开(公告)号：US11578065B2

公开(公告)日：2023-02-14

申请号：US16646980

申请日：2018-09-04

申请人： HODOGAYA CHEMICAL CO., LTD.

发明人： Kazuyuki Suruga ,  Takeshi Yamamoto ,  Kouki Kase ,  Shunji Mochizuki

IPC分类号： C07D413/10 ,  C07D413/04 ,  C07C211/54 ,  C07C211/58 ,  C07D209/82 ,  C07D263/57 ,  C07D277/66 ,  C07D307/91 ,  C07D333/76 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  H01L51/00 ,  H01L51/42

摘要： An organic EL device is provided, including at least an anode, a hole transport layer, a light-emitting layer, an electron transport layer, and a cathode in this order, wherein the hole transport layer contains an arylamine compound represented by the following formula (1), wherein Ar1 to Ar8 and n1 are defined in the specification, and the electron transport layer contains a compound having a benzoazole ring structure represented by the following formula (2), wherein Ar9, Ar10, X, Y1, Z1 and Z2 are defined in the specification.

公开(公告)号：US20230024752A1

公开(公告)日：2023-01-26

申请号：US17504243

申请日：2021-10-18

申请人： Bayer Pharma Aktiengesellschaft

发明人： Eloisa JIMENEZ NUNEZ ,  Jens ACKERSTAFF ,  Susanne ROEHRIG ,  Alexander HILLISCH ,  Katharina MEIER ,  Stefan HEITMEIER ,  Adrian TERSTEEGEN ,  Jan STAMPFUSS ,  Pascal ELLERBROCK ,  Daniel MEIBOM ,  Dieter LANG

IPC分类号： C07D401/10 ,  C07D401/14 ,  C07D413/14 ,  C07D413/10 ,  A61P7/02

摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

公开(公告)号：US20220402903A1

公开(公告)日：2022-12-22

申请号：US17754970

申请日：2020-10-13

申请人： SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. ,  JIANGSU YANGNONG CHEMICAL CO., LTD.

发明人： Jichun YANG ,  Aiying GUAN ,  Dongliang CUI ,  Qiao WU ,  Hongjuan MA ,  Enming WU ,  Changling LIU

IPC分类号： C07D413/10 ,  A01N43/80

摘要： An isoxazoline compound with optical activity is shown in the formula (I). The compound of the formula (I) has excellent herbicidal activity, can be used for weeding pre- and post-emergence, and can also be used for soil treatment. The compound of the formula (I) can effectively control various broad-leaved weeds, grass weeds and Cyperaceae weeds, and can control various resistant weeds, such as glyphosate-resistant weeds. The excellent weeding effect can be obtained at a low dose. The compound has good safety to crops such as corn, wheat, rice, soybean and sugar beet. The compound can be used as a selective herbicide in crop fields in agriculture, and can also be used as a non-selective herbicide in non-cultivated land, fallow land, woodland, orchards and ridges.

公开(公告)号：US11518751B2

公开(公告)日：2022-12-06

申请号：US17058888

申请日：2018-05-28

申请人： Transitions Optical, Ltd.

发明人： Robert W. Walters ,  Chien-Yang Chiu ,  Anu Chopra ,  Darrin R. Dabideen ,  Sujit Mondal ,  Nick J. Parise ,  Wenjing Xiao

IPC分类号： C07D311/94 ,  C07D413/10 ,  G02B1/04 ,  G02B5/23 ,  G03C1/73

摘要： A photochromic compound including a core skeletal structure represented by the following Formula (I), wherein D is oxygen or sulfur; E is oxygen, sulfur, or NR2′; a is 0 or 1; R1 is hydrogen, or substituted or unsubstituted alkyl; R2 and R2′ are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocycloalkyl; and the photochromic compound is a thermally reversible photochromic compound.

公开(公告)号：US20220352474A1

公开(公告)日：2022-11-03

申请号：US17231835

申请日：2021-04-15

申请人： ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.

发明人： Dong-Hyung Lee ,  Chi-Sik KIM ,  Yoo-Jin DOH ,  Seung-Hoon YOO ,  Soo-Yong LEE ,  Hyun-Woo KANG

IPC分类号： H01L51/00 ,  C07D307/91 ,  C09K11/06 ,  C07D491/048 ,  C07D251/24 ,  C07D413/10 ,  C07D491/06

摘要： The present disclosure relates to an organic electroluminescent device. The organic electroluminescent device of the present disclosure may exhibit low voltage, high efficiency, and/or long lifespan by including a light-emitting layer comprising a specific combination of the compounds, and an electron transport zone.