Invention Grant
- Patent Title: Cellular-based method for determining the biological activity of defibrotide
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Application No.: US15529814Application Date: 2015-11-23
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Publication No.: US10393731B2Publication Date: 2019-08-27
- Inventor: Terenzio Ignoni , Vijay Kumar , Claudio Verga
- Applicant: GENTIUM S.R.L.
- Applicant Address: IT Villa Guardia (CO)
- Assignee: GENTIUM S.R.L.
- Current Assignee: GENTIUM S.R.L.
- Current Assignee Address: IT Villa Guardia (CO)
- Agency: Cooley LLP
- Priority: EP14195277 20141127
- International Application: PCT/EP2015/077355 WO 20151123
- International Announcement: WO2016/083297 WO 20160602
- Main IPC: G01N33/50
- IPC: G01N33/50
Abstract:
The present invention relates to cell-based methods for determining the biological activity of defibrotide. In particular, the invention provides a method for assessing the potency of defibrotide by assessing the viability of mammalian cells in the presence of at least one cytotoxic agent and one or more concentrations of defibrotide. Such methods are particularly useful for standardizing pharmaceutical compositions comprising defibrotide.
Public/Granted literature
- US20170322199A1 CELLULAR-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF DEFIBROTIDE Public/Granted day:2017-11-09
Information query
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