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公开(公告)号：US10393731B2
公开(公告)日：2019-08-27
申请号：US15529814
申请日：2015-11-23
Applicant: GENTIUM S.R.L.
Inventor： Terenzio Ignoni , Vijay Kumar , Claudio Verga
IPC: G01N33/50
Abstract: The present invention relates to cell-based methods for determining the biological activity of defibrotide. In particular, the invention provides a method for assessing the potency of defibrotide by assessing the viability of mammalian cells in the presence of at least one cytotoxic agent and one or more concentrations of defibrotide. Such methods are particularly useful for standardizing pharmaceutical compositions comprising defibrotide.
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