Invention Grant
- Patent Title: Diagnostic method for gastric cancer
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Application No.: US15113006Application Date: 2014-10-22
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Publication No.: US10393747B2Publication Date: 2019-08-27
- Inventor: Jung Hoe Kim , Sung Hyeon Lee , Seung Yeol Park , Jin Man Kim , Hyun Joo An , Jae-Han Kim , Myung Jin Oh
- Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Daejeon
- Assignee: Korea Advanced Institute of Science and Technology
- Current Assignee: Korea Advanced Institute of Science and Technology
- Current Assignee Address: KR Daejeon
- Agency: Knobbe Martens Olson & Bear LLP
- Priority: KR10-2014-0019067 20140219
- International Application: PCT/KR2014/009921 WO 20141022
- International Announcement: WO2015/126030 WO 20150827
- Main IPC: G01N33/574
- IPC: G01N33/574

Abstract:
This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in N-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the N-glycan as compared to normal persons, N-glycan structures identified using the changes in N-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis.
Public/Granted literature
- US20160356777A1 NOVEL DIAGNOSTIC METHOD FOR GASTRIC CANCER Public/Granted day:2016-12-08
Information query
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