公开(公告)号：US10393747B2

公开(公告)日：2019-08-27

申请号：US15113006

申请日：2014-10-22

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Jung Hoe Kim ,  Sung Hyeon Lee ,  Seung Yeol Park ,  Jin Man Kim ,  Hyun Joo An ,  Jae-Han Kim ,  Myung Jin Oh

IPC分类号： G01N33/574

摘要： This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in N-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the N-glycan as compared to normal persons, N-glycan structures identified using the changes in N-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis.

公开(公告)号：US20180164320A1

公开(公告)日：2018-06-14

申请号：US15580662

申请日：2015-12-16

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Jung Hoe Kim ,  Sung Hyeon Lee ,  Seung Yeol Park ,  Hyun Joo An ,  Jae-Han Kim ,  Myung Jin Oh ,  Jin Man Kim ,  Ju A Lee

IPC分类号： G01N33/574 ,  G01N30/86 ,  G01N30/72 ,  C07H5/04

CPC分类号： G01N33/57419 ,  C07H5/04 ,  G01N30/7233 ,  G01N30/8631 ,  G01N2030/027 ,  G01N2560/00

摘要： The present invention relates to a method of diagnosing colorectal cancer by detection of glycan changes, and more particularly to a method of diagnosing colorectal cancer using mass spectrometry, in which, when specific glycan structures increase, decrease or significantly change due to a change in N-linked glycosylation of a colorectal cancer patient-derived glycoprotein, as detected by mass spectrometry, the glycan structures are selected as diagnostic markers.