A keyboard control circuit adapted to a keyboard device with a plurality of keys is provided. The keyboard control circuit comprises a combination key control unit, a key setting module and a processing module. When at least two keys of the keyboard device and a preset time are inputted, a combination signal of time stamping and sequence of keystrokes related to a function key is generated. The key setting module is used for receiving and transmitting a preset rule to the combination key control unit. When the function key for executing a control function is triggered, the keyboard device transmits a converting signal to the combination key control unit to convert the converting signal to the combination signal of time stamping and sequence of keystrokes and transmits the combination signal of time stamping and sequence of keystrokes to the processing module, and then the processing module executes the control function.