Invention Grant
- Patent Title: Internalizing human monoclonal antibodies targeting prostate and other cancer cells
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Application No.: US15390378Application Date: 2016-12-23
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Publication No.: US10400045B2Publication Date: 2019-09-03
- Inventor: Bin Liu
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Weaver Austin Villeneuve & Sampson LLP
- Agent Tom Hunter
- Main IPC: C07K16/28
- IPC: C07K16/28 ; G01N33/574 ; C07K16/30 ; A61K51/10 ; A61K47/68
Abstract:
In various embodiments various cancer specific antibodies and immunoconjugates are provided. In certain embodiments the antibodies specifically bind and are internalized into a prostate cancer cell, where the antibodies specifically binds cells that express or overexpress a CD46, and where the antibodies specifically bind sushi domain 1 of said CD46 (CD46 CPP1).
Public/Granted literature
- US20170240643A1 INTERNALIZING HUMAN MONOCLONAL ANTIBODIES TARGETING PROSTATE AND OTHER CANCER CELLS Public/Granted day:2017-08-24
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