公开(公告)号：US11702480B2

公开(公告)日：2023-07-18

申请号：US16349958

申请日：2017-11-17

申请人： The Regents of the University of California

发明人： Bin Liu ,  Namkyung Lee ,  Yang Su ,  Scott Bidlingmaier

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61K31/713 ,  C07K16/46

CPC分类号： C07K16/30 ,  A61K31/713 ,  C07K16/2821 ,  C07K16/2866 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

摘要： The present disclosure relates to an engineered antibody that co-engages a cell type-selective (or specific) antigen (guide) and a signaling receptor (effector) on a target cell. In some instances, the engineered antibody is capable of modulating a signaling pathway on a target cell. In other embodiments, an engineered antibody of the present disclosure is administered to a subject for the treatment of a disease or condition.

公开(公告)号：US11434301B2

公开(公告)日：2022-09-06

申请号：US16348135

申请日：2017-11-10

申请人： The Regents of the University of California

发明人： Bin Liu ,  Daniel W. Sherbenou ,  Blake T. Aftab ,  Yang Su ,  Christopher R. Behrens

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/6886 ,  C07K16/00 ,  G01N33/574 ,  A61K39/00

摘要： Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

公开(公告)号：US20210100838A1

公开(公告)日：2021-04-08

申请号：US15733202

申请日：2018-12-26

申请人： The Regents of the University of California

发明人： Bin Liu ,  Scott Bidlingmaier ,  Yang Su

IPC分类号： A61K35/17 ,  C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  A61K47/68 ,  A61K47/69

摘要： In certain embodiments internalizing anti-CD146 antibodies and conjugates thereof are provided. It was discovered that anti-CD146 antibodies are capable of targeting both epithelioid and sarcamatous subtypes of mesothelioma cells. In certain embodiments methods of detecting and/or treating mesothelioma are provided.

公开(公告)号：US20200040094A1

公开(公告)日：2020-02-06

申请号：US16517401

申请日：2019-07-19

申请人： The Regents of the University of California

发明人： Bin Liu

IPC分类号： C07K16/28 ,  G01N33/574 ,  A61K51/10 ,  C07K16/30 ,  A61K47/68

摘要： In various embodiments various cancer specific antibodies and immunoconjugates are provided. In certain embodiments the antibodies specifically bind and are internalized into a prostate cancer cell, where the antibodies specifically binds cells that express or overexpress a CD46, and where the antibodies specifically bind sushi domain 1 of said CD46 (CD46 CPP1).

公开(公告)号：US10550195B2

公开(公告)日：2020-02-04

申请号：US15321684

申请日：2015-07-09

申请人： The Regents of The University of California

发明人： Bin Liu

IPC分类号： C40B40/10 ,  C07K16/30 ,  A61K45/06 ,  A61K49/00 ,  C07K16/00

摘要： Methods are provided for identifying and selecting antibodies that are internalized into cells via the macropinocytosis pathway. Additionally antibodies that are internalized via this pathway are provided as well as immunoconjugates comprising such antibodies.

公开(公告)号：US20190025295A1

公开(公告)日：2019-01-24

申请号：US16152119

申请日：2018-10-04

申请人： The Regents of the University of California

发明人： Guillermo C. Bazan ,  Brent S. Gaylord ,  Shu Wang ,  Bin Liu

IPC分类号： G01N33/542 ,  C09B11/02 ,  C09B69/10 ,  G01N33/58 ,  C12Q1/6818 ,  G01N33/52 ,  C09K11/06 ,  C09K9/02 ,  B82Y15/00

摘要： Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

公开(公告)号：US20180369409A1

公开(公告)日：2018-12-27

申请号：US15779490

申请日：2016-11-29

申请人： The Regents of the University of California

发明人： Bin Liu ,  Scott Bidlingmaier ,  Yang Su

IPC分类号： A61K47/68 ,  C07K16/40 ,  G01N33/574 ,  A61P35/00 ,  A61K35/17 ,  C07K16/28

摘要： This invention provides antibodies directed against a highly specific and previously unrecognized marker for cancerous cells. In certain embodiments an isolated antibody or fragment thereof that specifically binds human placentally expressed ALPP and/or ALPPL2, but not ALPL and ALPI that are expressed outside the placenta is provided as well as immunoconjugates comprising such antibodies.

公开(公告)号：US20170184571A1

公开(公告)日：2017-06-29

申请号：US15461426

申请日：2017-03-16

申请人： The Regents of the University of California

发明人： Guillermo C. Bazan ,  Brent S. Gaylord ,  Shu Wang ,  Bin Liu

IPC分类号： G01N33/52 ,  C09K11/06 ,  C09B69/10 ,  C09K9/02

CPC分类号： G01N33/542 ,  B82Y15/00 ,  C09B11/02 ,  C09B69/103 ,  C09K9/02 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1425 ,  C12Q1/6818 ,  G01N33/52 ,  G01N33/582 ,  C12Q2525/107 ,  C12Q2527/125 ,  C12Q2565/107

摘要： Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

公开(公告)号：US08835113B2

公开(公告)日：2014-09-16

申请号：US14017127

申请日：2013-09-03

申请人： The Regents of the University of California

发明人： Guillermo C. Bazan ,  Bin Liu

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/542 ,  C08G61/02 ,  G01N33/543 ,  C08G61/12 ,  G01N21/64

CPC分类号： G01N21/6486 ,  C08G61/02 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6825 ,  G01N33/542 ,  G01N33/54373 ,  Y10T436/143333 ,  C12Q2565/113 ,  C12Q2563/173 ,  C12Q2565/101

摘要： This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.

摘要翻译： 本发明涉及可用于检测和分析样品中的聚集体的聚集传感器，以及与这种传感器相关的方法，制品和组合物。 传感器包括第一和第二光学有源单元，其中能量可以从第一光学活性单元的激发状态转移到第二光学活性单元。 第二光学活性单元以较小的量存在，但是其聚集时其相对浓度增加，从而增加其从第一光学活性单元的能量吸收。 可以以各种格式检测能量转移的这种增加，以产生用于各种聚合物的聚集感测系统，包括用于定量。 本文进一步描述了本发明的其它变型。

公开(公告)号：US20240307550A1

公开(公告)日：2024-09-19

申请号：US18271206

申请日：2022-01-06

申请人： The Regents of the University of California

发明人： Bin Liu ,  Yang Su ,  Scott Bidlingmaier

IPC分类号： A61K47/68 ,  A61K31/18 ,  A61K31/4166 ,  A61K31/567 ,  A61K31/573 ,  A61K31/58 ,  A61P35/00

CPC分类号： A61K47/6849 ,  A61K31/18 ,  A61K31/4166 ,  A61K31/567 ,  A61K31/573 ,  A61K31/58 ,  A61P35/00

摘要： A method to upregulate CD46 cell surface expression and combination therapies for various cancers employing an anti-CD46 antibody, an androgen signaling inhibitor (ASI), a STAT3 inhibitor and/or a glucocorticoid receptor agonist or modular (SEGRAM) are provided.