A processing method and device for multi-screen splicing display are disclosed. The method includes: receiving instruction information for multi-screen splicing display, where the instruction information is used to instruct to splice at least two physical display screens for display; sending, according to the instruction information, display data to a video RAM of a virtual display screen formed by splicing the at least two physical display screens, where a size of the video RAM of the virtual display screen corresponds to a size of the virtual display screen; dividing the display data into at least two data blocks that correspond to sizes of the at least two physical display screens, and respectively sending the data blocks obtained by division to video RAMs of corresponding physical display screens.