Systems and methods for displaying an image stream captured by an in vivo imaging device are presented. A method comprises receiving a stream of image frames captured by the in vivo device, each frame comprising a plurality of pixels. A summarized image presentation comprising summarized data elements may be generated, each summarized data element corresponding to at least one frame from the image stream. Summarized data elements are generated by ordering pixels of one or more image frames according to a first sorting parameter, sampling the ordered pixels according to a predetermined sampling scheme to acquire a subset of ordered pixels; and combining or appending sampled pixels to form a summarized data element. The summarized data elements are combined to form a summarized image presentation.