Invention Grant
- Patent Title: Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors
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Application No.: US15568072Application Date: 2015-09-18
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Publication No.: US10407419B2Publication Date: 2019-09-10
- Inventor: Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
- Applicant: FORMA Therapeutics, Inc.
- Applicant Address: US MA Watertown
- Assignee: Forma Therapeutics, Inc.
- Current Assignee: Forma Therapeutics, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Choate, Hall & Stewart LLP
- Agent John P. Rearick; Erica M. D'Amato
- International Application: PCT/US2015/051059 WO 20150918
- International Announcement: WO2016/171756 WO 20161027
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07D417/14 ; C07D471/04 ; A61P35/00
Abstract:
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where Y1, X1, X2, Y2, W1, W2, W3, and R1-R5 are described herein.
Public/Granted literature
- US20180118732A1 QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS Public/Granted day:2018-05-03
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