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1.发明公开公开(公告)号：US20240150319A1
公开(公告)日：2024-05-09
申请号：US18506060
申请日：2023-11-09
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC分类号： C07D401/12 , A61P35/00 , C07D401/14 , C07D471/04
CPC分类号： C07D401/12 , A61P35/00 , C07D401/14 , C07D471/04 , A61K31/47
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula:
where A, U, W1, W2, W3, R1-R6, and R9 are described herein.-
公开(公告)号：US20230125739A1
公开(公告)日：2023-04-27
申请号：US17984069
申请日：2022-11-09
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC分类号： C07D401/12 , C07D401/14 , C07D471/04 , A61P35/00
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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公开(公告)号：US20220304987A1
公开(公告)日：2022-09-29
申请号：US17698505
申请日：2022-03-18
发明人： Anna Ericsson , Neal Green , Gary Gustafson , David R. Lancia, JR. , Gary Marshall , Lorna Mitchell , David Richard , Zhongguo Wang , Sanjeev Forsyth , Patrick F. Kelly , Madhu Mondal , Maria Ribadeneira , Patricia Schroeder
IPC分类号： A61K31/436 , A61P9/00
摘要： The compound (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one, or a pharmaceutically acceptable salt thereof, is useful to increase the affinity of hemoglobin for oxygen. Methods and compositions for the treatment of a hemoglobinopathies are provided herein, including certain pharmaceutical compositions for activating PKR.
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公开(公告)号：US11161848B2
公开(公告)日：2021-11-02
申请号：US16540327
申请日：2019-08-14
发明人： Alexandre Joseph Buckmelter , Stephanos Ioannidis , Bruce Follows , Gary Gustafson , Minghua Wang , Justin A. Caravella , Zhongguo Wang , Edward L. Fritzen , Jian Lin
IPC分类号： C07D473/00 , A61K31/522
摘要： The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.
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公开(公告)号：US20210221816A1
公开(公告)日：2021-07-22
申请号：US17223783
申请日：2021-04-06
发明人： David R. Lancia, JR. , Gary Gustafson , Neal Green , Lorna Mitchell , Anna Ericsson , David Richard
IPC分类号： C07D487/04 , A61K9/00
摘要： The disclosure provides chemical compounds useful as activators of PKR. PKR activating compounds are useful in the treatment of disease and disorders associated with modulation of PKR and/or PKM2, such as pyruvate kinase deficiency (PKD).
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公开(公告)号：US20210078973A1
公开(公告)日：2021-03-18
申请号：US17101018
申请日：2020-11-23
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC分类号： C07D401/12 , C07D401/14 , C07D471/04 , A61P35/00
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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公开(公告)号：US20210017184A1
公开(公告)日：2021-01-21
申请号：US17062059
申请日：2020-10-02
发明人： Xiaozhang Zheng , Neal Green , Gary Gustafson , David R. Lancia, JR. , Lorna Mitchell , Tatiana Shelekhin
IPC分类号： C07D487/04 , C07D519/00 , A61P7/00 , A61K9/00 , A61K31/407
摘要： Compositions for the activation of PKR are provided, as well as therapeutic administration of the compositions for the treatment of pyruvate kinase-related medical conditions, such as pyruvate kinase deficiency (PKD).
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公开(公告)号：US10550099B2
公开(公告)日：2020-02-04
申请号：US16290328
申请日：2019-03-01
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC分类号： A61K31/506 , C07D401/12 , C07D405/14 , C07D401/14 , C07D417/14 , C07D413/14 , C07D471/04 , C07D409/14 , C07D403/12
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.
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公开(公告)号：US10472371B2
公开(公告)日：2019-11-12
申请号：US16245654
申请日：2019-01-11
发明人： Xiaozhang Zheng , Neal Green , Gary Gustafson , David R. Lancia, Jr. , Lorna Mitchell , Tatiana Shelekhin
IPC分类号： C07D487/04 , C07D519/00 , A61P7/00 , A61K9/00 , A61K31/407
摘要： Compositions for the activation of PKR are provided, as well as therapeutic administration of the compositions for the treatment of pyruvate kinase-related medical conditions, such as pyruvate kinase deficiency (PKD).
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10.发明申请公开(公告)号：US20190263778A1
公开(公告)日：2019-08-29
申请号：US16290240
申请日：2019-03-01
发明人： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, JR. , Justin Andrew Caravella , Wei Lu
IPC分类号： C07D401/12 , C07D471/04 , A61P35/00 , C07D401/14
摘要： The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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