Systems and methods for controlling valve assemblies associated with an actuator in an electro-hydraulic system are disclosed. In one method, a controller monitors hydraulic fluid flow for an actuator to identify one valve assembly connected to the actuator as a meter-in valve and another valve assembly connected to the actuator as a meter-out valve. In one aspect, the valve assembly most recently identified as the meter-in valve is controlled to maintain a pressure setpoint and the valve assembly most recently identified as the meter-out valve is controlled to maintain a hydraulic fluid flow rate. The method can also include determining whether the actuator is in a passive state or an overrunning state and controlling the valve most recently identified as the meter-in valve to maintain a first pressure setpoint when the actuator is in a passive state and to maintain a second pressure setpoint when the actuator is in an overrunning state.