Invention Grant
- Patent Title: Plasmonic imaging and detection of single DNA molecules
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Application No.: US15038629Application Date: 2015-01-02
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Publication No.: US10408757B2Publication Date: 2019-09-10
- Inventor: Nongjian Tao , Hui Yu , Xiaonan Shan , Shaopeng Wang
- Applicant: Arizona Board of Regents on Behalf of Arizona State University
- Applicant Address: US AZ Scottsdale
- Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Current Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Current Assignee Address: US AZ Scottsdale
- Agency: Quarles & Brady LLP
- Agent Yakov S. Sidorin
- International Application: PCT/US2015/010018 WO 20150102
- International Announcement: WO2015/103459 WO 20150709
- Main IPC: G01N21/552
- IPC: G01N21/552 ; C12M1/34

Abstract:
Method and system to remove background noise with a differential approach in optical imaging is disclosed. The differential approach moves the sample position laterally over a small distance, and a differential image is generated from the images recorded before and after the lateral translation. This approach can significantly improve the image quality of objects, including single DNA molecules, for label-free optical imaging techniques, such as surface plasmon resonance imaging. Disclosed imaging technique provides high-resolution genome-wide restriction maps of single DNA molecules.
Public/Granted literature
- US20160299069A1 PLASMONIC IMAGING AND DETECTION OF SINGLE DNA MOLECULES Public/Granted day:2016-10-13
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