Methods, systems, and computer readable media for using access point name (APN) independent subscriber bindings. In some examples, a method is performed by a Diameter signaling router (DSR) for a telecommunications network. The method includes receiving, from a policy related node, a policy related message including a subscriber identifier associated with a subscriber; determining that the policy related message lacks APN information; after determining that the policy related message lacks APN information, using the subscriber identifier and preconfigured APN information to generate or identify a binding between the subscriber and a policy and charging rules function (PCRF) server of a pool of PCRF servers, or using the subscriber identifier to identify a first bound policy and charging rules function (PCRF) server of a pool of PCRF servers; and sending, to the identified PCRF server, the policy related message received from the policy related node.