Invention Grant
- Patent Title: Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease
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Application No.: US16324604Application Date: 2017-08-10
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Publication No.: US10414775B2Publication Date: 2019-09-17
- Inventor: John P. Caldwell , Mary Ann Caplen , Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Claire Lankin , Derun Li , Hong Liu , Amy McCracken , Brian McKittrick , Ashwin Rao , Jayaram Tagat , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu , Tianyuan Zhang
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Janet E. Fair; Catherine D. Fitch
- International Application: PCT/US2017/046183 WO 20170810
- International Announcement: WO2018/034917 WO 20180222
- Main IPC: C07D519/00
- IPC: C07D519/00 ; C07D487/04 ; C07D498/04
Abstract:
Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
Public/Granted literature
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