- 专利标题： Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease
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申请号： US16324604申请日： 2017-08-10
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公开(公告)号： US10414775B2公开(公告)日： 2019-09-17
- 发明人: John P. Caldwell , Mary Ann Caplen , Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Claire Lankin , Derun Li , Hong Liu , Amy McCracken , Brian McKittrick , Ashwin Rao , Jayaram Tagat , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu , Tianyuan Zhang
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Janet E. Fair; Catherine D. Fitch
- 国际申请： PCT/US2017/046183 WO 20170810
- 国际公布： WO2018/034917 WO 20180222
- 主分类号： C07D519/00
- IPC分类号： C07D519/00 ; C07D487/04 ; C07D498/04
摘要：
Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
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