- Patent Title: Gene construct encoding mutant thioesterase, mutant thioesterase encoded thereby, transformed host cell containing the gene construct, and method of using them to produce medium-chain fatty acids
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Application No.: US15630442Application Date: 2017-06-22
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Publication No.: US10421951B2Publication Date: 2019-09-24
- Inventor: Brian F. Pfleger , Nestor Jose Hernandez-Lozada , Costas Maranas , Matthew Grisewood
- Applicant: Wisconsin Alumni Research Foundation , The Penn State Research Foundation
- Applicant Address: US WI Madison US PA University Park
- Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION,THE PENN STATE RESEARCH FOUNDATION
- Current Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION,THE PENN STATE RESEARCH FOUNDATION
- Current Assignee Address: US WI Madison US PA University Park
- Agency: DeWitt LLP
- Agent Daniel A. Blasiole; Joseph T. Leone
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12N9/16
Abstract:
Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ. ID. NO: 1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in a transformed host cell and host cells transformed to contain the gene constructs.
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