Invention Grant
- Patent Title: Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
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Application No.: US15367030Application Date: 2016-12-01
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Publication No.: US10426958B2Publication Date: 2019-10-01
- Inventor: James Donald Loudin , Manfred Franke , Douglas Michael Ackermann
- Applicant: Oculeve, Inc.
- Applicant Address: US CA San Francisco
- Assignee: Oculeve, Inc.
- Current Assignee: Oculeve, Inc.
- Current Assignee Address: US CA San Francisco
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Main IPC: A61N1/36
- IPC: A61N1/36 ; A61N1/05 ; A61B5/00 ; A61B5/0488 ; A61B5/053

Abstract:
Described here are devices and methods for increasing ocular mucin and other tear protein release using intranasally delivered electrical stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may trigger degranulation of conjunctival goblet cells, which in turn releases secretory mucins into the tear fluid. The intranasal stimulation may also trigger release of lysozyme, lactoferrin, and other tear proteins into the aqueous layer of the tear film. The methods may further comprise obtaining feedback relating to the efficacy of the delivered electrical stimulation by measuring impedance or an electromyogram (EMG) signal.
Public/Granted literature
- US20170157401A1 INTRANASAL STIMULATION FOR ENHANCED RELEASE OF OCULAR MUCINS AND OTHER TEAR PROTEINS Public/Granted day:2017-06-08
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