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公开(公告)号：US20240252814A1
公开(公告)日：2024-08-01
申请号：US18463085
申请日：2023-09-07
申请人： Oculeve, Inc.
CPC分类号： A61N1/0546 , A61N1/36014 , A61N1/0456 , A61N1/36034
摘要： Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
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公开(公告)号：US20210069496A1
公开(公告)日：2021-03-11
申请号：US17018888
申请日：2020-09-11
申请人： Oculeve, Inc.
发明人： James Donald Loudin , Amitava Gupta , John L. Wardle , Christopher William Stivers , Anand Doraiswamy , Marie Dvorak Christ , F. Richard Christ
IPC分类号： A61N1/05 , H01B1/12 , A61N1/04 , C08F220/54 , C08F230/08 , C08F220/20
摘要： Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
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公开(公告)号：US10940310B2
公开(公告)日：2021-03-09
申请号：US16357033
申请日：2019-03-18
申请人： Oculeve, Inc.
摘要： Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
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公开(公告)号：US10207108B2
公开(公告)日：2019-02-19
申请号：US14920852
申请日：2015-10-22
申请人： Oculeve, Inc.
发明人： Manfred Franke , James Donald Loudin , Janusz Kuzma , Paul Taehyun Yun , Douglas Michael Ackermann
摘要： Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.
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公开(公告)号：US20140316310A1
公开(公告)日：2014-10-23
申请号：US14256916
申请日：2014-04-18
申请人： Oculeve, Inc.
CPC分类号： A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
摘要： Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US10426958B2
公开(公告)日：2019-10-01
申请号：US15367030
申请日：2016-12-01
申请人： Oculeve, Inc.
IPC分类号： A61N1/36 , A61N1/05 , A61B5/00 , A61B5/0488 , A61B5/053
摘要： Described here are devices and methods for increasing ocular mucin and other tear protein release using intranasally delivered electrical stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may trigger degranulation of conjunctival goblet cells, which in turn releases secretory mucins into the tear fluid. The intranasal stimulation may also trigger release of lysozyme, lactoferrin, and other tear proteins into the aqueous layer of the tear film. The methods may further comprise obtaining feedback relating to the efficacy of the delivered electrical stimulation by measuring impedance or an electromyogram (EMG) signal.
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公开(公告)号：US10252048B2
公开(公告)日：2019-04-09
申请号：US15438577
申请日：2017-02-21
申请人： Oculeve, Inc.
摘要： Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
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公开(公告)号：US09770583B2
公开(公告)日：2017-09-26
申请号：US14630471
申请日：2015-02-24
申请人： Oculeve, Inc.
IPC分类号： A61N1/04 , A61N1/05 , A61K9/00 , C08J3/075 , H01B1/12 , C08F220/54 , C08F230/08 , A61N1/36
CPC分类号： A61N1/0546 , A61N1/0456 , A61N1/0496 , A61N1/36014 , C08F220/54 , C08F230/08 , H01B1/125 , Y10T29/49826 , Y10T29/49885 , C08F226/10 , C08F220/20 , C08F2222/1013 , C08F2230/085
摘要： Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
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公开(公告)号：US09764150B2
公开(公告)日：2017-09-19
申请号：US14920847
申请日：2015-10-22
申请人： Oculeve, Inc.
发明人： James Donald Loudin , Manfred Franke , Daniel N. Hamilton , Anand Doraiswamy , Douglas Michael Ackermann
CPC分类号： A61N1/3787 , A61N1/36046 , A61N1/36121 , B29D11/00038 , B29D11/00826
摘要： Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.
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公开(公告)号：US09440065B2
公开(公告)日：2016-09-13
申请号：US14313937
申请日：2014-06-24
申请人： Oculeve, Inc.
发明人： Douglas Michael Ackermann , James Donald Loudin , John Wardle , Jarren Armond Baldwin , Daniel N. Hamilton , Janusz Kuzma , Christopher William Stivers , Manfred Franke
IPC分类号： A61N1/05 , A61N1/36 , A61H1/00 , A61F7/12 , A61N1/378 , A61H9/00 , A61H21/00 , A61H23/02 , H02J7/00 , A61M31/00 , A61N7/00
CPC分类号： A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
摘要： Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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