Invention Grant
- Patent Title: Autotaxin inhibitors
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Application No.: US16171236Application Date: 2018-10-25
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Publication No.: US10428061B2Publication Date: 2019-10-01
- Inventor: Francesca Blum , James Lindsay Carr , Pritom Shah , Maria Del Mar Jimenez Quesada , Irene Farre Gutierrez
- Applicant: CANCER RESEARCH TECHNOLOGY LIMITED
- Applicant Address: GB London
- Assignee: Cancer Research Technology Limited
- Current Assignee: Cancer Research Technology Limited
- Current Assignee Address: GB London
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
- Priority: GB1501870.8 20150204; GB1502716.2 20150218
- Main IPC: C07D417/14
- IPC: C07D417/14 ; C07D403/12 ; C07D405/14 ; C07D413/12 ; C07D417/12 ; C07D491/107 ; C07D401/14 ; C07D413/14 ; A61K31/433 ; A61K31/454 ; A61K31/496 ; A61K31/501 ; A61K31/5377 ; A61K31/55 ; A61K31/551 ; A61K31/553 ; A61K45/06
Abstract:
The present invention relates to compounds of formula I wherein R1, R2, R3, R4a, R4b, R4c, R4d, L, A, Q, W and HET are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.
Public/Granted literature
- US20190062324A1 AUTOTAXIN INHIBITORS Public/Granted day:2019-02-28
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