- Patent Title: Modified natural killer cells that express IL15 and uses thereof
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Application No.: US15309362Application Date: 2015-05-14
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Publication No.: US10428305B2Publication Date: 2019-10-01
- Inventor: Dario Campana , David Shook , Masaru Imamura
- Applicant: National University of Singapore , St. Jude Children's Research Hospital, Inc.
- Applicant Address: SG Singapore US TN Memphis
- Assignee: National University of Singapore,St. Jude Children's Research Hospital, Inc.
- Current Assignee: National University of Singapore,St. Jude Children's Research Hospital, Inc.
- Current Assignee Address: SG Singapore US TN Memphis
- Agency: Hamilton, Brooke, Smith & Reynolds, P.C.
- International Application: PCT/SG2015/050111 WO 20150514
- International Announcement: WO2015/174928 WO 20151119
- Main IPC: C12N15/24
- IPC: C12N15/24 ; C12N5/10 ; C07K14/54 ; C12N5/0783 ; C12N15/62 ; A61K35/17 ; C12N5/00 ; A61K38/20 ; C07K14/705 ; C07K19/00
Abstract:
The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.
Public/Granted literature
- US20170073638A1 Modified Natural Killer Cells and Uses Thereof Public/Granted day:2017-03-16
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