Invention Grant
- Patent Title: Continuous diode laser stimulated Raman gain/loss vibrational microscope
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Application No.: US15243207Application Date: 2016-08-22
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Publication No.: US10433731B2Publication Date: 2019-10-08
- Inventor: Robert R. Alfano , Lingyan Shi , Yury Budansky
- Applicant: Robert R. Alfano
- Agency: Myron Greenspan Lackenbach Siegel LLP
- Main IPC: A61B5/00
- IPC: A61B5/00 ; G01N21/65

Abstract:
There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous Raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5. With the availability of continuous wave diode laser at numerous wavelengths from 375 nm-1800 nm for parametric nonlinear difference vibrational mixing to enhance Stimulated Raman process within materials. A seed beam at Raman frequency is used with pump laser beam. In this way one can map in 2D and 3D images of the vibrations associate with disease changes. Scanning a pair of laser beams can map the location of vibrations within cells, smears, membranes, arteries, and tissues of animal and human.
Public/Granted literature
- US20170127947A1 CONTINUOUS DIODE LASER STIMULATED RAMAN GAIN/LOSS VIBRATIONAL MICROSCOPE Public/Granted day:2017-05-11
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