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    COMPACT OPTICAL VIRUS DETECTION ANALYZER OF NANO- AND MICRO- SIZE BIO PARTICLES USING LIGHT SCATTERING AND FLUORESCENCE
    1.
    发明申请
    COMPACT OPTICAL VIRUS DETECTION ANALYZER OF NANO- AND MICRO- SIZE BIO PARTICLES USING LIGHT SCATTERING AND FLUORESCENCE 有权

    公开(公告)号：US20220120656A1

    公开(公告)日：2022-04-21

    申请号：US17503086

    申请日：2021-10-15

    Applicant: Robert R. Alfano ,  Lingyan Shi ,  Binlin Wu

    Inventor： Robert R. Alfano ,  Lingyan Shi ,  Binlin Wu

    IPC: G01N15/06 ,  B01L3/00

    Abstract: A Compact Optical Virus Detection Analyzer (COVDA) uses light scattering and fluorescence to detect nanometer (nm) and micrometer (um) sized particles, such as biological particles and can be used to detect viruses such as coronavirus including SAR-CoV-2 responsible for COVID-19, pollen and bacteria. It can be used for prescreening, rapid detection of suspicious people. COVDA involves experimental and theoretical methods for particle and virus detection using Tryptophan as a key biomarker. Light sources in compact units include lamps such as Xenon (Xe) lamp with narrow band filters, LEDs (such as AlN) or laser diode, Q switched and mode lock Lasers for nanosecond and picosecond pulses (such as Nd Yag/Glass, Ti sapphire with Harmonic generator) in blue from 400 nm to 500 nm to generate second harmonic generation (SHG) in KDP/BBO crystals to produce 200 nm to 250 nm emission, or green laser pointers at about 530 nm to get emitters with harmonic crystals at about 270 nm or LEDS from 230 nm to 300 nm for pumping the samples at 230 nm to 289 nm to pump tryptophan and light scatter of nanometer particles of virus. The ultra high power ns and ps lasers in mJ to J can level can be used to locate Bio virus bacteria clouds in free space to image and destroy and kill virus.

    TABLE-TOP UTRA SUPERCONTINUUM AND HIGHER HARMONIC GENERATION SOURCE FOR MICROSCOPY
    2.
    发明申请
    TABLE-TOP UTRA SUPERCONTINUUM AND HIGHER HARMONIC GENERATION SOURCE FOR MICROSCOPY 有权

    公开(公告)号：US20220166177A1

    公开(公告)日：2022-05-26

    申请号：US17532834

    申请日：2021-11-22

    Applicant: Robert R. Alfano

    Inventor： ROBERT R. ALFANO ,  Shah Faisal B. Mazhar ,  Mikhail Sharonov ,  Lingyan Shi

    IPC: H01S3/00 ,  G21K7/00 ,  A61B6/00 ,  G02F1/35 ,  H01S3/11

    Abstract: In this patent, we teach methods to generate coherent X-ray and UUV rays beams for X ray and UUV microscopes using intense femtosecond pulses resulting the Ultra-Supercontinuum (USC) and Higher Harmonic Generation (HHG) from χ3 and χ5 media produce from electronic and molecular Kerr effect. The response of n2 (χ3) and n4 (χ5) at the optical frequency from instantaneously response of carrier phase of envelope results in odd HHG and spectral broadening about each harmonic on the anti-Stokes side of the pump pulse at wo typically in the visible, NIR, and MIR. From the slower molecular Kerr response on femtosecond to picosecond from orientation and molecular motion on n2 and n4 which follow the envelope of optical field of the laser gives rise to extreme broadening without HHG. The resulting spectra extend on the Stokes side towards the IR, RF to DC covering most of the electromagnetic spectrum. These HHG and Super broadening covering UUV to X rays and possibly to gamma ray regime for microscopes.

    Continuous diode laser stimulated Raman gain/loss vibrational microscope
    3.
    发明授权
    Continuous diode laser stimulated Raman gain/loss vibrational microscope 有权

    公开(公告)号：US10433731B2

    公开(公告)日：2019-10-08

    申请号：US15243207

    申请日：2016-08-22

    Applicant: Robert R. Alfano

    Inventor： Robert R. Alfano ,  Lingyan Shi ,  Yury Budansky

    IPC: A61B5/00 ,  G01N21/65

    Abstract: There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous Raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5. With the availability of continuous wave diode laser at numerous wavelengths from 375 nm-1800 nm for parametric nonlinear difference vibrational mixing to enhance Stimulated Raman process within materials. A seed beam at Raman frequency is used with pump laser beam. In this way one can map in 2D and 3D images of the vibrations associate with disease changes. Scanning a pair of laser beams can map the location of vibrations within cells, smears, membranes, arteries, and tissues of animal and human.

    Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence
    5.
    发明授权
    Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence 有权

    公开(公告)号：US12066368B2

    公开(公告)日：2024-08-20

    申请号：US17503086

    申请日：2021-10-15

    Applicant: Robert R. Alfano ,  Lingyan Shi ,  Binlin Wu

    Inventor： Robert R. Alfano ,  Lingyan Shi ,  Binlin Wu

    IPC: G01N15/06 ,  B01L3/00 ,  G01N15/00 ,  G01N15/01 ,  G01N15/075

    CPC classification number: G01N15/0612 ,  B01L3/508 ,  B01L2200/025 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/168 ,  G01N15/01 ,  G01N15/075

    Abstract: A Compact Optical Virus Detection Analyzer (COVDA) uses light scattering and fluorescence to detect nanometer (nm) and micrometer (um) sized particles, such as biological particles and can be used to detect viruses such as coronavirus including SAR-CoV-2 responsible for COVID-19, pollen and bacteria. It can be used for prescreening, rapid detection of suspicious people. COVDA involves experimental and theoretical methods for particle and virus detection using Tryptophan as a key biomarker. Light sources in compact units include lamps such as Xenon (Xe) lamp with narrow band filters, LEDs (such as AlN) or laser diode, Q switched and mode lock Lasers for nanosecond and picosecond pulses (such as Nd Yag/Glass, Ti sapphire with Harmonic generator) in blue from 400 nm to 500 nm to generate second harmonic generation (SHG) in KDP/BBO crystals to produce 200 nm to 250 nm emission, or green laser pointers at about 530 nm to get emitters with harmonic crystals at about 270 nm or LEDS from 230 nm to 300 nm for pumping the samples at 230 nm to 289 nm to pump tryptophan and light scatter of nanometer particles of virus. The ultra high power ns and ps lasers in mJ to J can level can be used to locate Bio virus bacteria clouds in free space to image and destroy and kill virus.

    SECOND, THIRD AND FOURTH NEAR-INFRARED SPECTRAL WINDOWS FOR DEEP OPTICAL IMAGING OF TISSUE WITH LESS SCATTERING
    8.
    发明申请
    SECOND, THIRD AND FOURTH NEAR-INFRARED SPECTRAL WINDOWS FOR DEEP OPTICAL IMAGING OF TISSUE WITH LESS SCATTERING 审中-公开
    第二，第三和第四个近红外光谱窗口用于具有较少散射的组织的深度光学成像

    公开(公告)号：US20170049326A1

    公开(公告)日：2017-02-23

    申请号：US15243165

    申请日：2016-08-22

    Applicant: Robert R. Alfano

    Inventor： Robert R. Alfano ,  Laura Sordillo ,  Yang Pu ,  Lingyan Shi

    IPC: A61B5/00 ,  A61C19/04 ,  A61B5/05

    CPC classification number: A61B5/0075 ,  A61B5/0086 ,  A61B5/0088 ,  A61B5/0091 ,  A61B5/02007 ,  A61B5/4504 ,  A61B2090/3614 ,  A61B2562/0238 ,  A61C19/041 ,  G01N21/359 ,  G01N21/4795

    Abstract: Light at wavelengths in the near-infrared (NIR) region in the second NIR spectral window from 1,100 nm to 1,350 nm and a new spectral window from 1,600 nm to 1,870 nm, known as the third NIR optical window, and fourth at 2200 cm−1 are disclosed. Optical attenuation from thin tissue slices of normal and malignant breast and prostate tissue, and pig brain were measured in the spectral range from 400 nm to 2,500 nm. Optical images of chicken tissue overlying three black wires were also obtained using the second and third spectral windows. Due to a reduction in scattering and minimal absorption, longer attenuation and clearer images can be seen in the second, third and fourth NIR windows compared to the conventional first NIR window. The second and third spectral windows will have uses in microscope imaging arteries, bones, breast, cells, cracks, teeth, and blood due to less scattering of light.

    Abstract translation: 在第一NIR光谱窗口中的近红外（NIR）区域中的波长从1,100nm到1,350nm的光和从1600nm到1,870nm的新的光谱窗，被称为第三个NIR光学窗口，第四个在2200cm- 1。 在400nm至2500nm的光谱范围内测量来自正常和恶性乳腺和前列腺组织以及猪脑的薄组织切片的光学衰减。 使用第二和第三光谱窗口也获得覆盖三根黑色线的鸡肉组织的光学图像。 由于散射减小和吸收最小，与传统的第一NIR窗口相比，在第二，第三和第四NIR窗口中可以看到更长的衰减和更清晰的图像。 由于光的散射较少，第二和第三光谱窗口将在显微镜成像动脉，骨骼，乳腺，细胞，裂纹，牙齿和血液中具有应用。

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