- Patent Title: Substituted tetrahydrocarbazole and carbazole carboxamide compounds
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Application No.: US16140750Application Date: 2018-09-25
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Publication No.: US10435415B2Publication Date: 2019-10-08
- Inventor: Douglas G. Batt , Myra Beaudoin Bertrand , George V. De Lucca , Michael A. Galella , Soo Sung Ko , Charles M. Langevine , Qingjie Liu , Qing Shi , Anurag S. Srivastava , Joseph A. Tino , Scott Hunter Watterson
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- Main IPC: C07D403/10
- IPC: C07D403/10 ; C07D513/04 ; C07D471/04 ; C07D239/70 ; C07D209/88 ; A61P19/02 ; A61P37/06 ; A61P25/28 ; C07D209/86

Abstract:
Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is Cl or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
Public/Granted literature
- US20190023719A1 SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS Public/Granted day:2019-01-24
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