Described herein are systems and methods for securing sutures that obviate the need for tying knots. A device can be applied to adjacent suture portions that heats the suture portions and causes the suture portions to fuse together, effectively securing the suture portions together without a knot. The device can include a handle, an outer shaft coupled to the handle, an inner shaft movable proximally and distally within the outer shaft; a suture holder at the distal end portion of the outer shaft, and an electrical heating element positioned within the outer shaft. Actuation of the device causes the inner shaft and the heating element to move distally relative to the outer shaft and the suture holder, such that the heating element moves into the proximity of the suture holder to fuse together sutures held by the suture holder.