A predictive system and method thereof for indoor horticulture are disclosed. The method includes obtaining a set of input values identifying a geographic position of a physical structure enclosing an interior environment and a target distribution for environmental parameters for a selected plant occupant. The method further includes obtaining a virtual representation of the physical structure, and iteratively over time, updating the virtual representation based on actual plant growth or a predicted plant growth model for the selected plant occupant. The method further includes running a computational model to obtain a predicted distribution of the environmental parameters for the virtual representation, and determining a target distribution of artificially modulated environmental parameters. Based on the target distribution of the artificially modulated environmental parameters, the method includes setting output parameters for control devices to collectively control the actual distribution of the set of environmental parameters.