A numeric-control work center can be used for carrying out cutting operations or grinding and/or milling operations on plates of stone, marble, or, in general, natural or synthetic stone material, or ceramic material. The work center comprises at least one working head movable along at least two mutually orthogonal horizontal axes on a work surface. The work surface includes a rigid supporting board, which defines a first planar supporting surface, and a series of sacrificial elements rigidly connected to the rigid supporting board. The sacrificial elements are arranged in positions spaced apart from each other and define a second supporting surface located at a higher level than the first planar supporting surface, so that a cutting tool coupled to the working head engraves the sacrificial elements, without interfering with the supporting board during a cutting operation on a plate resting on the sacrificial elements, whichever is the path followed by the cutting tool. Between the sacrificial elements there remain free portions of the planar surface of the supporting board, so that they can be removably engaged by one or more blocks for supporting and holding the plate. These blocks project above the sacrificial elements and are adapted to define a third supporting surface, located at a higher level than the second supporting surface, for supporting and holding a plate during a milling or grinding operation on the plate.