Invention Grant
- Patent Title: Stabilized fibronectin based scaffold molecules
-
Application No.: US15127183Application Date: 2015-03-19
-
Publication No.: US10450363B2Publication Date: 2019-10-22
- Inventor: Dasa Lipovsek
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Cynthia L. Kanik
- International Application: PCT/US2015/021466 WO 20150319
- International Announcement: WO2015/143156 WO 20150924
- Main IPC: C40B40/10
- IPC: C40B40/10 ; C07K14/78 ; A61K47/64

Abstract:
Provided herein are proteins comprising a fibronectin based scaffold (FBS) domain, e.g., 10Fn3 molecules, that bind specifically to a target, and wherein the FBS domain is linked at its C-terminus to a region consisting of PmXn, wherein P is proline, X is any amino acid and wherein n is 0 or an integer that is at least 1 and m is an integer that is at least 1, and wherein the PmXn moiety provides an enhanced property to the FBS domain, e.g., enhanced stability, relative to the protein that is not linked to the PmXn moiety.
Public/Granted literature
- US20170183393A1 STABILIZED FIBRONECTIN BASED SCAFFOLD MOLECULES Public/Granted day:2017-06-29
Information query