A method of migrating a virtualized computing instance between source and destination virtualized computing systems includes executing a first migration workflow in the source virtualized computing system between a source host computer and a first mobility agent simulating a destination host, executing a second migration workflow in the destination virtualized computing system between a second mobility agent simulating a source host and a destination host computer, sending, as part of the first migration workflow, a configuration of the migrated virtualized computing instance to the destination virtualized computing system, translating, as part of the second migration workflow, infrastructure-dependent information in the configuration of the migrated virtualized computing instance, and transferring, during execution of the first and second migration workflows, migration data including the virtualized computing instance between the source host and the destination host over a network.