Concepts and technologies are disclosed herein for initiating signaling in mobile management entity pools using workflows. A processor can execute an orchestrator application. The processor can receive location data that indicates a geographic location at which a virtual mobility management entity has been instantiated and registered. The processor can obtain a mobility management entity topology that defines boundaries of two or more mobile management entity pools and identify, based on the location data, one of the mobility management entity pools in which the virtual mobility management entity is located. The processor can identify pool elements included in the mobility management entity pool, obtain a workflow for establishing and configuring the pool elements, and request establishment of signaling between the virtual mobile management entity and the pool elements.