Adhesive articles suitable for use in medical applications include a siloxane-based pressure sensitive adhesive layer, and a breathable conformable backing having a first surface and a second surface. The siloxane-based pressure sensitive adhesive layer is coated on the first surface of the breathable conformable backing, and the second surface of the breathable conformable backing comprises a treated surface. The siloxane-based pressure sensitive adhesive layer can be attached to skin and other adhesive articles can be releasably adhered to the treated surface to form adhesive constructions.