The present invention provides a power switch control circuit and an open detection method thereof. The power switch control circuit is for generating an operation signal at an operation signal output pin according to an input signal, wherein the operation signal is for operating a power switch. The power switch control circuit includes: a current injection circuit, which is connected to the operation signal output pin, and provides a predetermined current to the operation signal output pin according to an enable signal; and an open detection circuit, which is coupled to the current injection circuit, and determines whether a connection between the operation signal output pin and the power switch is open according to a level of the operation signal output pin at a detection time point or according to a level variation of the operation signal output pin during a detection time period, whereby an open detection signal is generated.