Invention Grant
- Patent Title: Polypeptides, cells, and methods involving engineered CD16
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Application No.: US15300024Application Date: 2015-03-27
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Publication No.: US10464989B2Publication Date: 2019-11-05
- Inventor: Bruce Kenneth Walcheck , Dan Samuel Kaufman , Jianming Wu , Yawu Jing , Zhenya Ni
- Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
- Applicant Address: US MN Minneapolis
- Assignee: Regents of the University of Minnesota
- Current Assignee: Regents of the University of Minnesota
- Current Assignee Address: US MN Minneapolis
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2015/022998 WO 20150327
- International Announcement: WO2015/148926 WO 20151001
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04 ; C07K14/735 ; C12N5/0783 ; A61K35/17 ; A61K38/17 ; A61K39/395 ; C07K16/32 ; C12N5/0787 ; C12N5/0786 ; A01K67/00 ; A61K39/00
Abstract:
This disclosure describes, generally, a modified form of CD 16, genetically-modified cells that express the modified CD 16, and methods that involve the genetically-modified cells. The modified form of CD 16 can exhibit increased anti-tumor and/or anti- viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.
Public/Granted literature
- US20170174743A1 POLYPEPTIDES, CELLS, AND METHODS INVOLVING ENGINEERED CD16 Public/Granted day:2017-06-22
Information query
