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1.发明公开公开(公告)号：US20230338114A1
公开(公告)日：2023-10-26
申请号：US18027576
申请日：2021-09-22
CPC分类号： A61C1/082 , A61C13/34 , A61C9/0053 , A61C9/0006 , G06F30/23 , G16H50/50
摘要： A dental preparation block guide comprises a chamber that is customized to receive at least one tooth of a patient for a shape-optimized restoration of the at least one tooth; and a channel formed in a surface of the block guide at a location selected relative to the shape-optimized restoration to be performed, the channel comprising an aperture extending through the surface to the chamber such that a dental handpiece can be inserted into and guided within the channel while a tool of the dental handpiece can interact with the at least one tooth in the chamber through the aperture to form a shape-optimized preparation in the at least one tooth to receive the shape-optimized restoration. Related methods and system, as well as other devices, also are disclosed.
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公开(公告)号：US20240358040A1
公开(公告)日：2024-10-31
申请号：US18649533
申请日：2024-04-29
摘要： A system for modifying dairy protein functionality can include a milk protein input, a treatment process, and a milk protein output. A controller can be in communication with the treatment process and can be configured to receive one or more input parameters. The controller can generate one or more treatment parameters based on the one or more input parameters. The controller can then initiate the treatment process based on one or more of the treatment parameters. The modified dairy protein functionality can be selected or optimized based on a target functionality of the milk protein output.
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公开(公告)号：US20240355227A1
公开(公告)日：2024-10-24
申请号：US18643653
申请日：2024-04-23
发明人： Alex Siu Lun Fok , Anqi Zhang , Ruoqiong Chen , Tamer Abdelrehim , Bruno Pierre Lima , Stephanie Porter , Hooi Pin Chew , Dina Elsherbini , Saba Tohidkhah
IPC分类号： G09B23/28
CPC分类号： G09B23/283
摘要： Example artificial dental calculus models are described. In one example, an in vitro artificial dental calculus includes a dental substrate and a mineralized biofilm comprising an extracellular support material and at least one bacterial species. In one example, a method for creating an in vitro dental calculus model includes applying saliva to a dental substrate in a production environment, applying a mixture of an extracellular support material and at least one bacterial species to the dental substrate, applying a solution comprising calcium and phosphate to the mixture on the dental substrate, and removing the dental substrate from the production environment after a period of time during which a mineralized biofilm comprising the extracellular support material and the at least one bacterial species forms on the dental substrate.
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公开(公告)号：US20240331666A1
公开(公告)日：2024-10-03
申请号：US18621628
申请日：2024-03-29
IPC分类号： G10H1/00
CPC分类号： G10H1/0025 , G10H2210/076 , G10H2210/105 , G10H2210/111 , G10H2210/385 , G10H2210/391 , G10H2220/116 , G10H2220/126
摘要： A musical composition is varied using a computational model of rubato. Rubato is modeled by changes to the symbolic onset and/or symbolic offset of each note, which allows for a greater flexibility in timing modifications, such as asymptotic tempo and localized retrogrades. A user selects notes to be modified (e.g., by plotting points to modify notes over a selected interval), and a curve fitting (e.g., a cubic spline interpolation) is used to determine modifications for other notes in the composition. These symbolic onset/offset modifications may also be translated into tempo modifications. The symbolic onset and/or offset modifications are applied to the composition to produce an adjusted musical composition, to which rubato has been applied. Rubato profiles can similarly be extracted from existing musical recordings and used to characterize the recordings, such as for training machine learning models and recommender systems.
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公开(公告)号：US20240315728A1
公开(公告)日：2024-09-26
申请号：US18611953
申请日：2024-03-21
发明人： Jonathan Strutt , Kari Roberts , Clay Ansley , Kyle Johnson , Sam Keller , Christina Letness , Matthew McCollor
CPC分类号： A61B17/3401 , A61M1/04 , A61B2017/00407 , A61B2017/3492 , A61M2205/073 , A61M2240/00
摘要： A neonatal pneumothorax decompression device is disclosed. The device comprises a needle stabilizer, a pressure indicator, and a fluid evacuation pump. The needle stabilizer is configured to facilitate insertion of the needle into a subject's pleural cavity and to hold a needle at an adjustable length. The pressure indicator is coupled to the proximal end of the needle stabilizer and is configured to visibly display pressure within the subject's pleural cavity. The fluid evacuation pump is configured to be actuated by a user to evacuate air or fluid from the subject's pleural cavity through the needle. The fluid evacuation pump is proximally coupled to the pressure indicator and the needle stabilizer.
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公开(公告)号：US20240315281A1
公开(公告)日：2024-09-26
申请号：US18670499
申请日：2024-05-21
申请人： COVERCRESS INC. , BOARD OF TRUSTEES OF ILLINOIS STATE UNIVERSITY , REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： Tim Ulmasov , Gary Hartnell , John C. Sedbrook , Michael David Marks , Maliheh Esfahanian , Ratan Chopra
IPC分类号： A23K10/30 , A23K20/158
CPC分类号： A23K10/30 , A23K20/158
摘要： Pennycress seed, seed lots, and seed meal having reduced fiber content and improved suitability for use in producing animal feed are provided.
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公开(公告)号：US12100879B2
公开(公告)日：2024-09-24
申请号：US17339289
申请日：2021-06-04
CPC分类号： H01P3/003 , C25D11/045 , C25D11/18 , C25D11/20 , C25D11/24 , H01L23/66 , H01P11/001 , H01L2223/6627
摘要： A method for forming anodic aluminum oxide (AAO) on a substrate includes disposing an Al layer on the substrate, there being a Cu layer between the substrate and the Al layer, and a TiW alloy layer between and in contact with the Cu layer and the Al layer, anodizing the Al layer to provide an AAO layer comprising nanopores extending into the AAO layer to a barrier layer of the AAO at a base of each nanopore and converting at least some of the TiW alloy layer to TiW oxide, over-anodizing the barrier layer to remove at least a portion of the AAO of the barrier layer at the base of each nanopore, and exposing the AAO layer, the TiW oxide, and the TiW to a chemical etchant sufficient to extend the nanopores through the AAO layer to a surface of the Cu layer.
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公开(公告)号：US12083291B2
公开(公告)日：2024-09-10
申请号：US17046411
申请日：2019-04-09
发明人： Marcos Molina , Jennifer Kim , Joshua Cadavez , Grace Joseph , Nicholas Gulachek , Arthur G. Erdman , Paul Rothweiler , Aaron Paul Tucker
CPC分类号： A61M25/02 , A61B5/031 , A61J15/0061 , A61M1/04 , A61M39/20 , A61M2025/024 , A61M2025/0266 , A61M2205/0205
摘要： A device includes a base and a tube clamp. The tube clamp is coupled to an upper surface of the base. The assembled tube clamp and base are positioned around a tube and moved into engagement with a surface of a patient, at which point a lower surface of the base is adhered to the surface of the patient to anchor the tube relative to the surface of the patient.
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公开(公告)号：US20240294503A1
公开(公告)日：2024-09-05
申请号：US18639608
申请日：2024-04-18
发明人： Joseph J. Topczewski , William C.K. Pomerantz , Angela S. Carlson , Huarui Cui , Anand Divakaran
IPC分类号： C07D401/14 , C07D403/14
CPC分类号： C07D401/14 , C07D403/14
摘要： The invention provides a compound of formula I:
or a salt thereof, wherein R1, R2, R3, A, B, D, E, F and G have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as bromodomain inhibitors.-
10.发明公开公开(公告)号：US20240293409A1
公开(公告)日：2024-09-05
申请号：US18372495
申请日：2023-09-25
发明人： Bruce R. Blazar , Ryan Flynn
IPC分类号： A61K31/519 , A61K35/12 , A61K35/28 , A61K45/06
CPC分类号： A61K31/519 , A61K35/28 , A61K45/06 , A61K2035/124
摘要： Described herein are methods for treating and preventing alloantibody driven chronic graft versus host disease (cGVHD). The methods include administering to an individual in need thereof ibrutinib for treating and preventing alloantibody driven graft versus host disease.
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