-
1.发明公开公开(公告)号：US20230338114A1
公开(公告)日：2023-10-26
申请号：US18027576
申请日：2021-09-22
CPC classification number: A61C1/082 , A61C13/34 , A61C9/0053 , A61C9/0006 , G06F30/23 , G16H50/50
Abstract: A dental preparation block guide comprises a chamber that is customized to receive at least one tooth of a patient for a shape-optimized restoration of the at least one tooth; and a channel formed in a surface of the block guide at a location selected relative to the shape-optimized restoration to be performed, the channel comprising an aperture extending through the surface to the chamber such that a dental handpiece can be inserted into and guided within the channel while a tool of the dental handpiece can interact with the at least one tooth in the chamber through the aperture to form a shape-optimized preparation in the at least one tooth to receive the shape-optimized restoration. Related methods and system, as well as other devices, also are disclosed.
-
公开(公告)号：US12233073B2
公开(公告)日：2025-02-25
申请号：US16620382
申请日：2018-06-08
Applicant: Regents of the University of Minnesota
Inventor： Ann M. Bode , Zigang Dong , Eunmiri Roh
Abstract: An example technique for treating a skin cancer condition includes administering a therapeutically effective amount of a p53-related protein kinase (PRPK) inhibitor to a patient having skin cancer or having a high risk of developing skin cancer. An example composition includes a therapeutically effective amount of a PRPK inhibitor for treating a skin cancer condition. An example composition includes a pharmaceutically effective amount of at least one anti-solar ultraviolet (anti-sUV) combination for preventing a skin cancer condition. The at least one anti-sUV combination is chosen from the combinations: avobenzone and octinoxate; octocrylene and zinc oxide; avobenzone, octocrylene, and titanium dioxide; or avobenzone, octocrylene, and zinc oxide.
-
公开(公告)号：US20250061618A1
公开(公告)日：2025-02-20
申请号：US18720261
申请日：2022-12-14
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Steen MOELLER , Mehmet AKÇAKAYA , Kamil UGURBIL
Abstract: Denoised magnetic resonance images are generated using a two-step process. An initial set of images is first denoised on a per channel basis using a locally low-rank-based denoising technique. The denoised coil channel images are transformed back into k-space and the denoised k-space data are then applied to a nonlinear image reconstruction. In some instances, the nonlinear image reconstruction can be implemented using a trained neural network. The neural network may be trained using a self-supervised learning technique.
-
公开(公告)号：US12215642B2
公开(公告)日：2025-02-04
申请号：US18465387
申请日：2023-09-12
Applicant: Regents of the University of Minnesota
Inventor： Rajesh Rajamani , Woongsun Jeon
Abstract: A method of estimating in-cylinder pressure includes receiving a vibration signal from a vibration sensor mounted proximate a compression ignition (CI) engine, receiving angular position information for the CI engine, and determining in-cylinder pressure based on the angular position information and on a combustion component of the vibration signal.
-
公开(公告)号：US12214201B2
公开(公告)日：2025-02-04
申请号：US16966390
申请日：2019-02-01
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Logan Grado , Theoden Netoff , Andy Lamperski , Bryan Moore
Abstract: Systems and methods for adaptively controlling an electrical stimulation device, such as a closed-loop stimulation device, based in part on a Bayesian optimization of the operational parameters of the device are described. An adaptive dual control of the stimulation device can be provided. In a first control loop parameters are extracted from signals recorded from the subject by the stimulation device, and in a second control loop a Bayesian optimization is implemented with a hardware processor and memory to compute updated operational parameters for the stimulation device. As noted, the stimulation device is an electrical stimulation device, and may be a closed-loop stimulation device. Such devices can be used for deep brain stimulation (“DBS”), cardiac resynchronization therapy (“CRT”), and other electrophysiological stimulation applications.
-
Patent Agency Ranking
公开(公告)号：US20250025447A1
公开(公告)日：2025-01-23
申请号：US18705175
申请日：2022-11-02
Applicant: Regents of the University of Minnesota
Inventor： David M. FERGUSON
IPC: A61K31/437 , A61K45/06 , A61P37/06 , C07D471/04
Abstract: The present disclosure provides compounds of Formula I which can be tuned to provide agonistic or antagonistic toll-like receptor (TLR) bining properties. Further provided herein are pharmaceutical compositions comprising compounds described herein, as well as methods of using such compositions to treat a disease or condition in a subject.
-
公开(公告)号：US12201509B2
公开(公告)日：2025-01-21
申请号：US18117930
申请日：2023-03-06
Applicant: Regents of the University of Minnesota
Inventor： Robert Tranquillo , Zeeshan Syedain , Lee Meier
Abstract: This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts.
-
公开(公告)号：US20250009698A1
公开(公告)日：2025-01-09
申请号：US18755956
申请日：2024-06-27
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Reena V. Kartha , James C. Cloyd
IPC: A61K31/201 , A61K47/40
Abstract: Pharmaceutical compositions including nervonic acid or a pharmaceutically acceptable salt thereof and a cyclodextrin. Methods of treating a subject having or at risk of having adrenoleukodystrophy and/or a neurological disease by administering a pharmaceutical composition of the present disclosure to the subject.
-
公开(公告)号：US20250005324A1
公开(公告)日：2025-01-02
申请号：US18217081
申请日：2023-06-30
Inventor： Siliang Zeng , Songtao Lu , Xiaodong Cui , Mark S. Squillante , Lior Horesh , Brian E. D. Kingsbury , Mingyi Hong
IPC: G06N3/045
Abstract: A computer-implemented method of decentralized multi-agent learning for use in a system having a plurality of intelligent agents each having a personal portion and a shared portion, is provided. The method includes iteratively, until each of a personal goal and a network goal are optimized: determining a feedback associated with an action relative to a personal goal and a degree of similarity relative to a shared goal; adjusting a policy based on the feedback to gain a superior feedback from a next action; broadcasting the shared policy; receiving the at least one of the one or more other intelligent agents' shared policy; generating a combined policy by combining the personal policy and the at least one of the one or more other intelligent agents' shared policy; estimating, using the combined policy, a network value function; and conducting the next action in accordance with the combined policy.
-
公开(公告)号：US12174281B2
公开(公告)日：2024-12-24
申请号：US17947761
申请日：2022-09-19
Applicant: Regents of the University of Minnesota , Duke University
Inventor： Oren Solomon , Noam Harel , Guillermo Sapiro , Edward Auerbach , Steen Moeller , Remi Patriat , Henry Braun , Tara Palnitkar
IPC: G01R33/565 , A61B5/055 , G01R33/56
Abstract: A system and method are provided for creating magnetic resonance (MR) images with reduced motion artifacts from the MR data from which the images are produced. The method includes selecting a candidate image from a plurality of candidate images reconstructed from the MR data. The method also includes registering the candidate image to a reference image, comparing the candidate image to a consistency map, and, based on comparing the candidate image using the consistency map, selecting a blending algorithm. The method also includes generating a blended image using the blending algorithm and the candidate image and repeating these steps for each candidate image. The method also includes performing a Fourier aggregation to generate a combined image and displaying the combined image with reduced motion artifacts compared to the plurality of candidate images.
-
-
-
-
-
-
-
-
-
Search Results
2480
records
(took 0.14 seconds)
