- 专利标题: Potent gamma-secretase modulators
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申请号: US15522969申请日: 2015-10-30
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公开(公告)号: US10472346B2公开(公告)日: 2019-11-12
- 发明人: Steven L. Wagner , William C. Mobley , Rudolph E. Tanzi , Graham Johnson , Ronald Buckle , Nicholas Mayhew , Robert Jason Herr , Kevin D. Rynearson
- 申请人: The General Hospital Coporation , The Regents of the University of California , Steven L. Wagner , William C. Mobley , Rudolph E. Tanzi , Graham Johnson , Ronald Buckle , Nicholas Mayhew , Robert Jason Herr
- 申请人地址: US MA Boston US CA Oakland
- 专利权人: The General Hospital Corporation,The Regents of the University of California
- 当前专利权人: The General Hospital Corporation,The Regents of the University of California
- 当前专利权人地址: US MA Boston US CA Oakland
- 代理机构: Fish & Richardson P.C.
- 国际申请: PCT/US2015/058429 WO 20151030
- 国际公布: WO2016/070107 WO 20160506
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D413/14 ; C07D487/04 ; A61P25/28
摘要:
Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant Aβ peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L′ is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted —C2-6 alkylene-, and substituted or unsubstituted —C3-6 cycloalkylene.
公开/授权文献
- US20180093967A1 POTENT GAMMA-SECRETASE MODULATORS 公开/授权日:2018-04-05