-
公开(公告)号:US10472346B2
公开(公告)日:2019-11-12
申请号:US15522969
申请日:2015-10-30
申请人: The General Hospital Coporation , The Regents of the University of California , Steven L. Wagner , William C. Mobley , Rudolph E. Tanzi , Graham Johnson , Ronald Buckle , Nicholas Mayhew , Robert Jason Herr
发明人: Steven L. Wagner , William C. Mobley , Rudolph E. Tanzi , Graham Johnson , Ronald Buckle , Nicholas Mayhew , Robert Jason Herr , Kevin D. Rynearson
IPC分类号: C07D401/14 , C07D413/14 , C07D487/04 , A61P25/28
摘要: Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant Aβ peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L′ is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted —C2-6 alkylene-, and substituted or unsubstituted —C3-6 cycloalkylene.
-
公开(公告)号:US20180093967A1
公开(公告)日:2018-04-05
申请号:US15522969
申请日:2015-10-30
发明人: Steven L. Wagner , William C. Mobley , Rudolph E. Tanzi , Graham Johnson , Ronald Buckle , Nicholas Mayhew , Robert Jason Herr , Kevin D. Rynearson
IPC分类号: C07D401/14 , C07D413/14 , C07D487/04 , A61P25/28
摘要: Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant Aβ peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L′ is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted —C2-6 alkylene-, and substituted or unsubstituted —C3-6 cycloalkylene.
-
公开(公告)号:US11117884B2
公开(公告)日:2021-09-14
申请号:US16664621
申请日:2019-10-25
发明人: Steven L. Wagner , William C. Mobley , Rudolph E. Tanzi , Graham Johnson , Ronald Buckle , Nicholas Mayhew , Robert Jason Herr , Kevin D. Rynearson
IPC分类号: C07D401/14 , C07D413/14 , C07D487/04 , A61P25/28
摘要: Provided herein are compounds and methods for treating a disorder associated with aberrant Aβ peptide levels, including Alzheimer's disease.
-
公开(公告)号:US20200055840A1
公开(公告)日:2020-02-20
申请号:US16664621
申请日:2019-10-25
发明人: Steven L. Wagner , William C. Mobley , Rudolph E. Tanzi , Graham Johnson , Ronald Buckle , Nicholas Mayhew , Robert Jason Herr , Kevin D. Rynearson
IPC分类号: C07D401/14 , A61P25/28 , C07D487/04 , C07D413/14
摘要: Provided herein are compounds and methods for treating a disorder associated with aberrant Aβ peptide levels, including Alzheimer's disease.
-
公开(公告)号:US09938291B2
公开(公告)日:2018-04-10
申请号:US14775546
申请日:2014-03-13
申请人: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号: C07D498/04 , C07D213/79 , C07D249/04 , C07D237/28 , C07D471/08 , C07D237/24 , C07D487/04 , C07C233/56 , C07D213/80 , C07D231/56 , C07D239/28 , C07D471/04 , C07D491/052
CPC分类号: C07D498/04 , C07C233/56 , C07D213/79 , C07D213/80 , C07D231/56 , C07D237/24 , C07D239/28 , C07D249/04 , C07D471/04 , C07D487/04 , C07D491/052
摘要: The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.
-
公开(公告)号:US20160368925A1
公开(公告)日:2016-12-22
申请号:US15254966
申请日:2016-09-01
申请人: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号: C07D487/04 , C07D471/04
CPC分类号: C07D487/04 , C07D471/04
摘要: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3r R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.
摘要翻译: 或其药学上可接受的盐。
-
公开(公告)号:US08795782B2
公开(公告)日:2014-08-05
申请号:US13355072
申请日:2012-01-20
IPC分类号: C09D201/02 , C08L101/02
CPC分类号: C08J7/16 , C08F2438/03
摘要: The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerization initiators and a plurality of surface binding groups. Pendant polymers may be grafted from at least some of the polymerization initiators.
摘要翻译: 本发明涉及一种可控制的聚合物表面涂层,其包括共价结合到基底表面的大分子,该大分子包括多个聚合引发剂和多个表面结合基团。 侧链聚合物可以从至少一些聚合引发剂接枝。
-
8.
公开(公告)号:US20120083495A1
公开(公告)日:2012-04-05
申请号:US13310965
申请日:2011-12-05
申请人: Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
发明人: Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
IPC分类号: A61K31/5377 , C07D401/10 , C07D403/10 , C07D409/10 , C07D413/10 , C07D405/10 , A61K31/4035 , A61K31/4439 , A61K31/506 , A61K31/454 , A61K31/403 , C12N5/071 , A61P25/16 , A61P25/28 , A61P25/00 , A61P25/08 , A61P35/00 , A61P3/10 , A61P21/00 , A61P31/12 , C07D209/46
CPC分类号: C07D209/46 , C07D401/04 , C07D403/04 , C07D409/04
摘要: Compounds useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.
摘要翻译: 可用于治疗脊髓性肌萎缩或其他用途的化合物,以及使用这些化合物增加SMN表达,增加EAAT2表达或增加编码通过突变或移码引入的翻译终止密码子的核酸的表达的方法。
-
9.
公开(公告)号:US08110681B2
公开(公告)日:2012-02-07
申请号:US12293268
申请日:2007-03-13
申请人: Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
发明人: Jill Heemskerk , Keith D. Barnes , John M. McCall , Graham Johnson , David Fairfax , Matthew Robert Johnson
IPC分类号: C07D413/04 , C07D239/24 , C07D401/04 , C07D209/46 , C07D206/56 , A61K31/535 , A61K31/44 , A61K31/40 , A01N43/54
CPC分类号: C07D209/46 , C07D401/04 , C07D403/04 , C07D409/04
摘要: Compounds of Formula (I) or (II) useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced by mutation or frameshift.
摘要翻译: 可用于治疗脊髓性肌萎缩或其他用途的式(I)或(II)化合物,以及使用这些化合物增加SMN表达的方法,增加EAAT2表达,或增加编码 通过突变或移码引入的翻译终止密码子。
-
公开(公告)号:US20080029167A1
公开(公告)日:2008-02-07
申请号:US11826289
申请日:2007-07-13
申请人: Carol Norma Eastwick , Kathryn Anne Simmons , Graham Johnson , Stephen John Pickering , Mark Farrall
发明人: Carol Norma Eastwick , Kathryn Anne Simmons , Graham Johnson , Stephen John Pickering , Mark Farrall
IPC分类号: F16C1/24
CPC分类号: F01D25/186 , F01D25/125 , F01D25/16 , F05D2240/50 , F16C19/06 , F16C33/6685 , F16C2360/23 , Y10T137/85938
摘要: A flow control arrangement 10 for controlling the flow of lubricant discharged from a bearing 12 includes a flow control member 24 locatable, in use, adjacent to the bearing 12. The flow control member 24 defines a generally circumferential outer edge 26a and is rotatable to direct lubricant discharged onto the flow control member 24 radially outwardly towards the outer edge 26a for ejection therefrom.
摘要翻译: 用于控制从轴承12排出的润滑剂的流动的流量控制装置10包括在使用中可与轴承12相邻定位的流量控制构件24。 流量控制构件24限定大致圆周的外边缘26a,并且可旋转以将排出到流量控制构件24上的润滑剂径向向外朝向外边缘26a排出以从其中弹出。
-
-
-
-
-
-
-
-
-