- Patent Title: Antibodies specific for hyperphosphorylated tau and methods of use
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Application No.: US15645442Application Date: 2017-07-10
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Publication No.: US10472415B2Publication Date: 2019-11-12
- Inventor: Jan Torleif Pedersen , Kristian Kjærgaard , Lars Østergaard Pedersen , Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Alfred Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: DK201600416 20160712; DK201700005 20170104; DK201700008 20170104; DK201700179 20170314
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K39/395 ; A61K49/00 ; A61K39/00 ; G01N33/68
Abstract:
The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
Public/Granted literature
- US20180016330A1 Antibodies Specific for Hyperphosphorylated Tau and Methods of Use Thereof Public/Granted day:2018-01-18
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