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公开(公告)号：US20190330320A1
公开(公告)日：2019-10-31
申请号：US16475299
申请日：2018-01-03
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist
Abstract: The present invention is based on antibodies which are both highly specific for hyperphosphorylated pathogenic P-S396 tau and highly specific for labelled sections of the human retina, as well as to methods of using these antibodies and their tau binding fragments in the treatment of retinoid amyloidosis, age related macular degeneration (ARMD), and glaucoma.
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公开(公告)号：US20220187322A1
公开(公告)日：2022-06-16
申请号：US17598837
申请日：2020-03-24
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Thomas Karikari , Kina Höglund , Kaj Blennow , Mikkel Harndahl Harndahl , Henrik Zetterberg
IPC: G01N33/68 , G01N33/543 , G01N1/40
Abstract: The present invention relates to an in vitro assay for measuring phosphorylated tau in a sample, said assay comprises the use of 2 antibodies i) a capture antibody specific for pS396 on tau and ii) a detection antibody binding tau on a different epitope that the capture antibody.
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公开(公告)号：US20180016330A1
公开(公告)日：2018-01-18
申请号：US15645442
申请日：2017-07-10
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjærgaard , Lars Østergaard Pedersen , Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Alfred Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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公开(公告)号：US12129289B2
公开(公告)日：2024-10-29
申请号：US17399205
申请日：2021-08-11
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Alfred Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68 , A61K39/00
CPC classification number: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/6896 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2800/2814 , G01N2800/2821
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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公开(公告)号：US20210206843A1
公开(公告)日：2021-07-08
申请号：US17144355
申请日：2021-01-08
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Alfred Daechsel , Ayodeji Abdur-rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K39/395 , G01N33/68 , A61K49/00
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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Patent Agency Ranking
公开(公告)号：US10995137B2
公开(公告)日：2021-05-04
申请号：US16475299
申请日：2018-01-03
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist
Abstract: The present invention is based on antibodies which are both highly specific for hyperphosphorylated pathogenic P-S396 tau and highly specific for labelled sections of the human retina, as well as to methods of using these antibodies and their tau binding fragments in the treatment of retinoid amyloidosis, age related macular degeneration (ARMD), and glaucoma.
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公开(公告)号：US10934348B2
公开(公告)日：2021-03-02
申请号：US16723143
申请日：2019-12-20
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Alfred Daechsel , Ayodeji Abdur-rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K39/395 , G01N33/68 , A61K49/00 , A61K39/00
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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公开(公告)号：US10647762B2
公开(公告)日：2020-05-12
申请号：US16371902
申请日：2019-04-01
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
IPC: C07K16/18 , A61K49/00 , A61K39/395 , A61K39/00 , G01N33/68
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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公开(公告)号：US20190284266A1
公开(公告)日：2019-09-19
申请号：US16371902
申请日：2019-04-01
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68
Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
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公开(公告)号：US10196439B2
公开(公告)日：2019-02-05
申请号：US15207836
申请日：2016-07-12
Applicant: H. Lundbeck A/S
Inventor： Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Alfred Daechsel , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
IPC: C07K16/18 , A61K39/395 , A61K49/00 , G01N33/68 , A61K39/00
Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
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