In an embodiment, a user equipment (UE) coupled to a display screen enters into a reduced blue light (RBL) mode. The UE determines, while operating in accordance with the RBL mode, a degree of blue light reduction in at least a portion of a display frame to be output on the display screen using at least one RBL rule from a set of RBL rules that is based upon one or more of (i) application-specific information of an application that is contributing image data to the portion of the display frame, and (ii) content-specific information that characterizes the image data in the portion of the display frame. The UE selectively reduces the blue light in the at least a portion of the display frame based on the determining. The UE sends the display frame with the selectively reduced blue light portion to the display screen for output.