Invention Grant
- Patent Title: PARG inhibitory compounds
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Application No.: US15533819Application Date: 2015-12-17
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Publication No.: US10508086B2Publication Date: 2019-12-17
- Inventor: Alison E. McGonagle , Allan M. Jordan , Bohdan Waszkowycz , Colin P. Hutton , Ian D. Waddell , James R. Hitchin , Kate M. Smith , Niall M. Hamilton
- Applicant: CANCER RESEARCH TECHNOLOGY LIMITED
- Applicant Address: GB London
- Assignee: Cancer Research Technology Limited
- Current Assignee: Cancer Research Technology Limited
- Current Assignee Address: GB London
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Priority: GB1422771.4 20141219
- International Application: PCT/GB2015/054064 WO 20151217
- International Announcement: WO2016/097749 WO 20160623
- Main IPC: C07D231/56
- IPC: C07D231/56 ; A61K31/416 ; C07D235/26 ; C07D413/14 ; C07D401/06 ; C07D403/06 ; C07D405/04 ; C07D405/06 ; C07D409/04 ; C07D413/04 ; C07D413/06 ; C07D417/04 ; C07D417/06 ; C07D417/14 ; A61P35/00 ; C07D307/85 ; C07D403/04

Abstract:
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
Public/Granted literature
- US20180194738A1 PARG INHIBITORY COMPOUNDS Public/Granted day:2018-07-12
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