- 专利标题： Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
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申请号： US16103619申请日： 2018-08-14
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公开(公告)号： US10508115B2公开(公告)日： 2019-12-17
- 发明人: Liqi He , Sanjeev Gangwar , Yam B. Poudel , Prasanna Sivaprakasam
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Yuan Chao
- 主分类号： A61K31/52
- IPC分类号： A61K31/52 ; A61K31/522 ; C07D473/14 ; A61P31/14 ; A61P31/20 ; C07D473/18 ; A61P37/04 ; A61K47/68
摘要：
Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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