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公开(公告)号：US10696676B2
公开(公告)日：2020-06-30
申请号：US16583869
申请日：2019-09-26
IPC分类号： C07D473/18 , A61P37/04
摘要： Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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2.发明申请公开(公告)号：US20190388553A1
公开(公告)日：2019-12-26
申请号：US16437047
申请日：2019-06-11
发明人： Ian S. Young , Sha Lou , Sanjeev Gangwar
摘要： In antibody-drug conjugates having tubulysin analog as the warhead, according to formula (III) the acetate group in the Tuv subunit (dotted box) demonstrates improved stability against hydrolytic cleavage.
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公开(公告)号：US10279049B2
公开(公告)日：2019-05-07
申请号：US15587927
申请日：2017-05-05
IPC分类号： A61K39/395 , A61K47/68 , C07K16/28
摘要： The drug component of an antibody-drug conjugate having a structure according to formula (II), where Ab, m, n, R1, R2, R3, R4, and R5 are as defined in the application, exhibits unexpectedly improved stability.
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4.发明申请公开(公告)号：US20190055245A1
公开(公告)日：2019-02-21
申请号：US16103581
申请日：2018-08-14
IPC分类号： C07D473/18 , A61K47/68
摘要： Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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5.发明授权Immunoconjugates, compositions for making them, and methods of making and use 有权免疫缀合物，制备它们的组合物，以及制备和使用方法公开(公告)号：US09186416B2
公开(公告)日：2015-11-17
申请号：US14471096
申请日：2014-08-28
发明人： Qian Zhang , Sanjeev Gangwar , Chin Pan , Daniel W. Derwin
IPC分类号： A61K47/48 , C07K5/06 , C07K5/10 , C07K5/08 , A61K31/404 , C07D403/06 , C07D403/14 , C07D209/60
CPC分类号： A61K47/48384 , A61K31/404 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , C07D209/60 , C07D403/06 , C07D403/14 , C07K5/06 , C07K5/06034 , C07K5/06095 , C07K5/08 , C07K5/0808 , C07K5/10
摘要： An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.
摘要翻译： 一种免疫偶联物，其中式（I）的磷酸酯前体化DNA小沟结合剂（其中X是可亲可取代的离去基团）与抗体或抗体的抗原结合片段缀合，以及可用于制备的化合物 这样的免疫缀合物，以及这种免疫缀合物的用途。
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6.发明申请IMMUNOCONJUGATES, COMPOSITIONS FOR MAKING THEM, AND METHODS OF MAKING AND USE 有权免疫球蛋白，制备它们的组合物，制备和使用方法公开(公告)号：US20140364585A1
公开(公告)日：2014-12-11
申请号：US14471096
申请日：2014-08-28
发明人： Qian ZHANG , Sanjeev Gangwar , Chin Pan , Daniel W. Derwin
IPC分类号： A61K47/48 , A61K31/404 , C07K5/08 , C07K5/06 , C07K5/10
CPC分类号： A61K47/48384 , A61K31/404 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , C07D209/60 , C07D403/06 , C07D403/14 , C07K5/06 , C07K5/06034 , C07K5/06095 , C07K5/08 , C07K5/0808 , C07K5/10
摘要： An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.
摘要翻译： 一种免疫偶联物，其中式（I）的磷酸酯前体化DNA小沟结合剂（其中X是可亲可取代的离去基团）与抗体或抗体的抗原结合片段缀合，以及可用于制备的化合物 这样的免疫缀合物，以及这种免疫缀合物的用途。
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7.发明申请ENEDIYNE COMPOUNDS, CONJUGATES THEREOF, AND USES AND METHODS THEREFOR 审中-公开ENEDIYNE化合物，其结合物及其用途及其用途公开(公告)号：US20140193438A1
公开(公告)日：2014-07-10
申请号：US14203118
申请日：2014-03-10
发明人： Naidu S. Chowdari , Sanjeev Gangwar , Bilal Sufi
IPC分类号： C07D491/08 , A61K31/439 , A61K47/48
CPC分类号： C07D491/08 , A61K31/439 , A61K47/48384 , A61K47/6803 , C07K16/18
摘要： Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
摘要翻译： 具有式（I）结构的烯二烯化合物，其中R 0，R 2，R 3，R 4，R 5，R 6和R 7在本文中定义，可用于化疗药物，特别是缀合物用于治疗疾病如癌症 。
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公开(公告)号：US08709431B2
公开(公告)日：2014-04-29
申请号：US13764226
申请日：2013-02-11
发明人： Naidu S. Chowdari , Sanjeev Gangwar , Bilal Sufi
IPC分类号： A61K39/00 , C07D489/12 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , A61K31/44 , A01N43/42 , C07K16/00 , C12P21/08
CPC分类号： C07D491/08 , A61K31/439 , A61K47/48384 , A61K47/6803 , C07K16/18
摘要： Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
摘要翻译： 具有式（I）结构的烯二烯化合物，其中R 0，R 2，R 3，R 4，R 5，R 6和R 7在本文中定义，可用于化疗药物，特别是缀合物用于治疗疾病如癌症 。
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公开(公告)号：US11485741B2
公开(公告)日：2022-11-01
申请号：US17043886
申请日：2019-04-23
发明人： Ashok V. Purandare , Honghe Wan , Liqi He , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam , Naidu S. Chowdari
IPC分类号： C07D487/16 , A61K47/60
摘要： Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.
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公开(公告)号：US10941145B2
公开(公告)日：2021-03-09
申请号：US16890765
申请日：2020-06-02
IPC分类号： C07D473/18 , A61P37/04
摘要： Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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